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KMID : 0358920090360040586
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Journal of the Korean Academy of Pedodontics
2009 Volume.36 No. 4 p.586 ~ p.590
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LEUKOCYTE ADHESION DEFICIENCY TYPE I : CASE REPORT
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Yoon Eun-Young
Lee Nan-Young
Lee Sang-Ho
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Abstract
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Leukocyte adhesion deficiency is rare inherited defect on phagocytic function resulting lack of leukocyte cell surface expression of β2 integrin molecule that are essential for leukocyte adhesion to endothelial cells and chemotaxis. Clinical features of patients with leukocyte adhesion deficiency type I include recurrent necrotic infection of the skin, mucous membranes, and intestinal tract with septicemia, and omphalitis arising from delayed umbilical cord seperation. Oral manifestations are severe progressive periodontitis with alveolar bone loss, periodontal pockets, and partial and total premature loss of the deciduous and permanent dentitions. We report a case of leukocyte adhesion deficiency type I in a 5-year-old child with severe periodontitis. In order to prevent local and systemic infection, we controlled periodontal disease with periodic oral prophylaxis. Oral swabs and blood cultures were perfomed for suspected infection, so that optimal measures were taken through the use of appropriate antibiotics.
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KEYWORD
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Leukocyte adhesion deficiency type I, Leukocyte, Periodontitis, Oral hygiene
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